Article
Prolactin as a biomarker for treatment response and tardive dyskinesia in schizophrenia subjects: old thoughts revisited from a genetic perspective.
Human psychopharmacology - 1 Jan 2011
Souza Renan P, Meltzer Herbert Y, Lieberman Jeffrey A, Voineskos Aristotle N, Remington Gary, Kennedy James L
Abstract excerpt
Previous studies investigated whether prolactin (PRL) serum level was a biomarker of antipsychotic response, schizophrenia symptomatology, and tardive dyskinesia. Most of the findings support that antipsychotic drugs modulate PRL levels but PRL is not a steady indicator. Recent results suggest a genetic effect of PRL and PRL receptor (PRLR) polymorphisms in PRL levels indicating that independently of...
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