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Article

Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics.

Schizophrenia research - 1 Apr 2017

Ivanova Svetlana A, Osmanova Diana Z, Boiko Anastasia S, Pozhidaev Ivan V, Freidin Maxim B, Fedorenko Olga Yu, Semke Arkadiy V, Bokhan Nikolay A, Kornetova Elena G, Rakhmazova Lubov D, Wilffert Bob, Loonen Anton J M

Abstract excerpt

BACKGROUND: Antipsychotic drugs can cause hyperprolactinemia. However, hyperprolactinemia was also observed in treatment-naive patients with a first schizophrenic episode. This phenomenon might be related to the role of prolactin as a cytokine in autoimmune diseases. Extrapituitary prolactin production is regulated by an alternative promoter, which contains the functional single nucleotide polymorphism -1149 G/T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27776952
DOI: 10.1016/j.schres.2016.10.029

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