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Article

Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans.

Circulation. Genomic and precision medicine - 1 Jul 2018

Khetarpal Sumeet A, Babb Paul L, Zhao Wei, Hancock-Cerutti William F, Brown Christopher D, Rader Daniel J, Voight Benjamin F

Abstract excerpt

BACKGROUND: Genome-wide association studies have uncovered common variants at many loci influencing human complex traits, such as high-density lipoprotein cholesterol (HDL-C). However, the contribution of the identified genes is difficult to ascertain from current efforts interrogating common variants with small effects. Thus, there is a pressing need for scalable, cost-effective strategies for uncovering causal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29987113
DOI: 10.1161/CIRCGEN.117.002070
PMCID: PMC6050033

Genes

CETP
GALNT2
LIPG
APOA5
APOC3
CCDC92
SCARB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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