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Prenatal diagnosis of Down syndrome using cell-free fetal DNA in amniotic fluid by quantitative fluorescent polymersase chain reaction

20 May 2014

Abstract excerpt

BACKGROUND: Amniotic fluid (AF) supernatant contains cell-free fetal DNA (cffDNA) fragments. This study attempted to take advantage of cffDNA as a new material for prenatal diagnosis, which could be combined with simple quantitative fluorescent polymerase chain reaction (QF-PCR) to provide an ancillary method for the prenatal diagnosis of trisomy 21 syndrome. METHODS: AF supernatant samples were obtained from 27...

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Share to Genomic variations and chromosomal abnormalities
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PMID: 24824252
DOI: 10.3760/cma.j.issn.0366-6999.20132609

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