Article
Digital PCR for the molecular detection of fetal chromosomal aneuploidy.
Proceedings of the National Academy of Sciences of the United States of America - 7 Aug 2007
Lo Y M Dennis, Lun Fiona M F, Chan K C Allen, Tsui Nancy B Y, Chong Ka C, Lau Tze K, Leung Tak Y, Zee Benny C Y, Cantor Charles R, Chiu Rossa W K
Abstract excerpt
Trisomy 21 is the most common reason that women opt for prenatal diagnosis. Conventional prenatal diagnostic methods involve the sampling of fetal materials by invasive procedures such as amniocentesis. Screening by ultrasonography and biochemical markers have been used to risk-stratify pregnant women before definitive invasive diagnostic procedures. However, these screening methods generally target epiphenomena,...
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