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Article

Application of multiplex SNaPshot assay in measurement of PLAC4 RNA-SNP allelic ratio for noninvasive prenatal detection of trisomy 21.

Prenatal diagnosis - 1 Feb 2014

Yang Lan, Sun Haiyan, Chen Daozhen, Lu Mudan, Wang Junfeng, Xu Fei, Hu Lingqing, Xiao Jianpin

Abstract excerpt

OBJECTIVE: For the samples in which the fetus was heterozygous for the placenta-specific 4 (PLAC4) single-nucleotide polymorphism (SNP), our research is to develop a rapid, accurate, and cost-effective assay for the noninvasive prenatal detection of fetal trisomy 21 (T21). METHOD: Maternal plasma samples were prepared from 60 euploid pregnancies (range: 15-23 weeks) to 17 T21 pregnancies (range: 19-26 weeks)....

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PMID: 24214739
DOI: 10.1002/pd.4271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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