Article
Paraoxonase 1 polymorphisms as the risk factor of coronary heart disease in a Thai population.
Acta cardiologica - 1 Dec 2010
Likidlilid Atip, Akrawinthawong Krittapoom, Poldee Saiphon, Sriratanasathavorn Charn
Abstract excerpt
OBJECTIVE: Two common polymorphisms of the paraoxonase (PON1) gene, L55M and Q192R, were proven to mitigate atherosclerosis pathogenesis by protecting lipoproteins against peroxidation. This study was to evaluate the associations between both PON1 gene polymorphisms in Thai hyperlipidaemia with and without coronary heart disease (CHD). METHODS: Both PON1 genotypes were determined using PCR-RFLP in 103 healthy...
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