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Article

R/R genotype of human paraoxonase (PON1) is more protective against lipoprotein oxidation and coronary artery disease in Japanese subjects.

Journal of atherosclerosis and thrombosis - 1 Jan 2003

Kuremoto Kenichi, Watanabe Yoshiro, Ohmura Hirotoshi, Shimada Kazunori, Mokuno Hiroshi, Daida Hiroyuki

Abstract excerpt

Human paraoxonase (PON1) is an high-density lipoprotein (HDL) -associated enzyme that is proposed to protect against the oxidation of lipoproteins. Recently, the association of coronary artery disease (CAD) and PON1 activity was reported. Furthermore, the R/R genotype of PON1 has been related to the risk for CAD. In this study we investigated the PON1 genotype and susceptibility to lipoprotein oxidation to...

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Source

Identifiers

PMID: 12740482
DOI: 10.5551/jat.10.85

Genes

PON1
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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