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Article

Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer

7 Feb 2011

Abstract excerpt

A key barrier to the realization of personalized medicine for cancer is the identification of biomarkers. Here we describe a two-stage strategy for the discovery of serum biomarker signatures corresponding to specific cancer-causing mutations and its application to prostate cancer (PCa) in the context of the commonly occurring phosphatase and tensin homolog (PTEN) tumor-suppressor gene inactivation. In the first...

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PMID: 21300890
DOI: 10.1073/pnas.1013699108

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