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Article

The influence of bisphosphonates on human osteoblast migration and integrin aVb3/tenascin C gene expression in vitro

7 Feb 2011

Abstract excerpt

BACKGROUND: Bisphosphonates are therapeutics of bone diseases, such as Paget's disease, multiple myeloma or osteoclastic metastases. As a severe side effect the bisphosphonate induced osteonecrosis of the jaw (BONJ) often requires surgical treatment and is accompanied with a disturbed wound healing.Therefore, the influence on adhesion and migration of human osteoblasts (hOB) after bisphosphonate therapy has been...

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PMID: 21299894
DOI: 10.1186/1746-160x-7-4

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