Article
[Effect of diclofenac on human osteoblasts and their stromal precursors in vitro in relation to arthroplasty].
Zeitschrift fur Rheumatologie - 1 Feb 1999
Sell S, Teschner M, Gaissmaier C, Martini F, Weidner S A, Küsswetter W
Abstract excerpt
INTRODUCTION: Results of animal experiments have demonstrated that the osseous integration of non-cemented prostheses can, at the very least temporarily, be impaired by the application of non-steroidal antiphlogistic agents (such as diclofenac). It is the objective of this study to examine whether there is a direct influence of diclofenac used in usual clinical dosages (3 times 50 mg daily) on bone cells and...
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