Article
Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.
PloS one - 31 Jan 2011
Paquet Agnes C, Baxter John, Weidler Jodi, Lie Yolanda, Lawrence Jody, Kim Rose, Bates Michael, Coakley Eoin, Chappey Colombe
Abstract excerpt
BACKGROUND: The CPCRA 064 study examined the effect of structured treatment interruption (STI) of up to 4 months followed by salvage treatment in patients failing therapy with multi-drug resistant HIV. We examined the relationship between the reversion rate of major reverse transcriptase (RT) resistance-associated mutations and change in viral replication capacity (RC). The dataset included 90 patients with RC...
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