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Article

RAD51 and XRCC3 polymorphisms: impact on the risk and treatment outcomes of de novo inv(16) or t(16;16)/CBFβ-MYH11(+) acute myeloid leukemia.

Leukemia research - 1 Aug 2011

Liu Liang, Yang Lin, Mi Yingchang, Wang Jianxiang, Li Jianyong, Zhang Yue, Ma Xiaotang, Qin Tiejun, Xu Zefeng, Xiao Zhijian

Abstract excerpt

DNA double-strand break repair via homologous recombination (HR) is essential in maintaining genetic integrity, and may modulate susceptibility to the development of acute myeloid leukemia (AML) and influence outcomes of AML. This study was designed to evaluate the effects of polymorphisms in HR repair genes RAD51 and XRCC3 on the risk and treatment outcomes of inv(16)/t(16;16)/CBFβ-MYH11(+) AML. The distribution...

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Topics

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Share to Chromosome Inversion
Share to Chromosomes, Human, Pair 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Leukemia, Myeloid, Acute

Share to Oncogene Proteins, Fusion

Share to Rad51 Recombinase

Share to Survival Rate

Share to Translocation, Genetic

Source

Identifiers

PMID: 21296419
DOI: 10.1016/j.leukres.2011.01.014

Genes

XRCC3
MYH11
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RAD51 and XRCC3 polymorphisms: impact on the risk and treatment outcomes of de novo inv(16) or t(16;16)/CBFβ-MYH11(+) acute myeloid leukemia.PMID 21296419Read ↗

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RAD51 and XRCC3 gene polymorphisms and the risk of developing acute myeloid leukemia.Semantic proximity Read ↗

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