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Article

Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2004

Seedhouse Claire, Faulkner Rowena, Ashraf Nadia, Das-Gupta Emma, Russell Nigel

Abstract excerpt

PURPOSE: Double-strand break repair via homologous recombination is essential in maintaining genetic integrity. RAD51 and XRCC3 are involved in the repair of DNA by this pathway, and polymorphisms have been identified in both the RAD51 (RAD51-G135C) and XRCC3 (XRCC3-Thr241Met) genes. The object of this study was to examine whether these polymorphisms may modulate susceptibility to the development of acute myeloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Share to Recombination, Genetic

Source

Identifiers

PMID: 15102670
DOI: 10.1158/1078-0432.ccr-03-0372

Genes

RAD51
XRCC3
GSTM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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