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Article

Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio.

PloS one - 1 Jan 2013

Stuckenholz Carsten, Lu Lili, Thakur Prakash C, Choi Tae-Young, Shin Donghun, Bahary Nathan

Abstract excerpt

Sfrp5 belongs to the family of secreted frizzled related proteins (Sfrp), secreted inhibitors of Wingless-MMTV Integration Site (Wnt) signaling, which play an important role in cancer and development. We selected sfrp5 because of its compelling expression profile in the developing endoderm in zebrafish, Danio rerio. In this study, overexpression of sfrp5 in embryos results in defects in both convergent extension...

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Identifiers

PMID: 23638093
DOI: 10.1371/journal.pone.0062470
PMCID: PMC3639276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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