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Article

BMP-binding modules in chordin: a model for signalling regulation in the extracellular space

15 Feb 2000

Abstract excerpt

A number of genetic and molecular studies have implicated Chordin in the regulation of dorsoventral patterning during gastrulation. Chordin, a BMP antagonist of 120 kDa, contains four small (about 70 amino acids each) cysteine-rich domains (CRs) of unknown function. In this study, we show that the Chordin CRs define a novel protein module for the binding and regulation of BMPs. The biological activity of Chordin...

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PMID: 10648240
DOI: 10.1242/dev.127.4.821

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