Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular localization and functional significance of CYP3A4 in the human epileptic brain

5 Feb 2011

Abstract excerpt

PURPOSE: Compelling evidence supports the presence of P450 enzymes (CYPs) in the central nervous system (CNS). However, little information is available on the localization and function of CYPs in the drug-resistant epileptic brain. We have evaluated the pattern of expression of the specific enzyme CYP3A4 and studied its co-localization with MDR1. We also determined whether an association exists between CYP3A4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Glioma Diagnosis and Treatment
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21294720
DOI: 10.1111/j.1528-1167.2010.02956.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular localization and functional significance of CYP3A4 in the human epileptic brainPMID 21294720Read ↗

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrierSemantic proximity Read ↗

Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological DiseasesSemantic proximity Read ↗

Significance of MDR1 and multiple drug resistance in refractory human epileptic brainSemantic proximity Read ↗

Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human EpilepsySemantic proximity Read ↗

Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cellsSemantic proximity Read ↗

Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics.Semantic proximity Read ↗

Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain.Semantic proximity Read ↗

Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.Semantic proximity Read ↗

Interplay of Drug Metabolizing CYP450 Enzymes and ABC Transporters in the Blood-Brain BarrierSemantic proximity Read ↗

<i>MDR1</i> Gene Expression in Brain of Patients with Medically Intractable EpilepsySemantic proximity Read ↗

Expression and functional characterization of ABCG2 in brain endothelial cells and vesselsSemantic proximity Read ↗

Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.