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Article

Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling.

American journal of physiology. Cell physiology - 1 Apr 2011

Chaston Timothy B, Matak Pavle, Pourvali Katayoun, Srai Surjit K, McKie Andrew T, Sharp Paul A

Abstract excerpt

Hepcidin negatively regulates systemic iron homeostasis in response to inflammation and elevated serum iron. Conversely, hepcidin expression is diminished in response to hypoxia, oxidative stress, and increased erythropoietic demand, though the molecular intermediates involved are incompletely understood. To address this, we have investigated hypoxic hepcidin regulation in HuH7 hepatoma cells either cultured...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21289291
DOI: 10.1152/ajpcell.00121.2010
PMCID: PMC3074628

Genes

SMAD4
BMP2
BMP6
HJV
EBP
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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