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Article

Colorimetric detection of DNA by modulation of thrombin activity on gold nanoparticles.

Chemistry (Weinheim an der Bergstrasse, Germany) - 18 Feb 2011

Jian Jyun-Wei, Huang Chih-Ching

Abstract excerpt

A colorimetric, non-cross-linking aggregation-based gold-nanoparticle (AuNP) probe has been developed for the detection of DNA and the analysis of single-nucleotide polymorphism (SNP). The probe acts by modulating the enzyme activity of thrombin relative to fibrinogen. A thrombin-binding aptamer with a 29-base-long oligonucleotide (TBA(29)) assembled on the nanoparticles (TBA(29)-AuNPs) through sandwich DNA...

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PMID: 21287648
DOI: 10.1002/chem.201002825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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