Article
KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation.
Endocrinology - 1 Apr 2011
Bianco Suzy D C, Vandepas Lauren, Correa-Medina Mayrin, Gereben Balázs, Mukherjee Abir, Kuohung Wendy, Carroll Rona, Teles Milena G, Latronico Ana Claudia, Kaiser Ursula B
Abstract excerpt
The goal of this study was to investigate how the Arg386Pro mutation prolongs KiSS-1 receptor (KISS1R) responsiveness to kisspeptin, contributing to human central precocious puberty. Confocal imaging showed colocalization of wild-type (WT) KISS1R with a membrane marker, which persisted for up to 5 h of stimulation. Conversely, no colocalization with a lysosome marker was detected. Also, overnight treatment with a...
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