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Article

Evidence for human kisspeptin receptor homo-oligomerisation and its functional relevance.

Journal of molecular endocrinology - 1 Aug 2025

Chakraborty Aishwarya P, Rathod Vidhi B, Sonawane Shobha, Bhanarkar Shital R, Pathak Bhakti R, Banerjee Antara A

Abstract excerpt

Abstract: The signalling of kisspeptin-1 through the kisspeptin-1 receptor (KISS1R) is central to mammalian reproduction. Naturally occurring heterozygous KISS1R mutations and Kiss1r +/- knockout mice are less affected than their homozygous counterparts, suggesting that the mutant receptors possibly form oligomers with the wild-type (WT) KISS1R, rescuing the receptor function to some extent. To test this...

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Source

Identifiers

PMID: 40680729
DOI: 10.1530/JME-25-0043

Genes

KISS1R
KISS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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