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Article

Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.

Archives of neurology - 1 Aug 2011

Deng Han-Xiang, Bigio Eileen H, Zhai Hong, Fecto Faisal, Ajroud Kaouther, Shi Yong, Yan Jianhua, Mishra Manjari, Ajroud-Driss Senda, Heller Scott, Sufit Robert, Siddique Nailah, Mugnaini Enrico, Siddique Teepu

Abstract excerpt

BACKGROUND: Mutations in optineurin have recently been linked to amyotrophic lateral sclerosis (ALS). OBJECTIVE: To determine whether optineurin-positive skeinlike inclusions are a common pathologic feature in ALS, including SOD1 -linked ALS. DESIGN: Clinical case series. SETTING: Academic referr...

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Identifiers

PMID: 21825243
DOI: 10.1001/archneurol.2011.178
PMCID: PMC3357952

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21825243-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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