Exploratory analysis of CaSR gene polymorphisms and haplotypes in relation to urolithiasis in the Qiongnan population of Hainan, China: a small-sample case-control study.

Abstract excerpt

BACKGROUND: Calcium urolithiasis arises from complex interactions between environmental and genetic factors regulating calcium metabolism. The calcium-sensing receptor (CaSR) is essential for maintaining calcium homeostasis, yet population-specific genetic effects remain insufficiently characterized. METHODS: A case–control study was conducted in the Qiongnan region of Hainan Province, including 50 patients with...

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