Article
Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair.
Journal of the American Heart Association - 25 Jan 2016
Zhang Zhiwei, Yang Junjie, Yan Weiya, Li Yangxin, Shen Zhenya, Asahara Takayuki
Abstract excerpt
BACKGROUND: Exosomes derived from mesenchymal stem cells (MSCs) were proved to boost cell proliferation and angiogenic potency. We explored whether cardiac stem cells (CSCs) preconditioned with MSC exosomes could survive and function better in a myocardial infarction model. METHODS AND RESULTS: DiI-labeled exosomes were internalized with CSCs. They stimulated proliferation, migration, and angiotube formation of...
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