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Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway.

Cancer letters - 1 Dec 2017

Yoshikawa Yoko, Takano Osamu, Kato Ichiro, Takahashi Yoshihisa, Shima Fumi, Kataoka Tohru

Abstract excerpt

Metastasis stands as the major obstacle for the survival from cancers. Nonetheless most existing anti-cancer drugs inhibit only cell proliferation, and discovery of agents having both anti-proliferative and anti-metastatic properties would be more beneficial. We previously reported the discovery of small-molecule Ras inhibitors, represented by Kobe0065, that displayed anti-proliferative activity on xenografts of...

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PMID: 28951129
DOI: 10.1016/j.canlet.2017.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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