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Article

A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression.

The American journal of pathology - 1 Feb 2011

Martin Ludovic, Douet Vanessa, VanWart Christopher M, Heller Matthew B, Le Saux Olivier

Abstract excerpt

β-Thalassemia and pseudoxanthoma elasticum (PXE) are distinct genetic disorders. Yet, a dystrophic mineralization phenotype similar to PXE has frequently been associated with β-thalassemia or sickle cell anemia patients of Mediterranean descent. These calcifications are clinically and structurally identical to inherited PXE. As we previously excluded the presence of PXE-causing mutations in the ABCC6 gene of...

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Source

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Identifiers

PMID: 21281810
DOI: 10.1016/j.ajpath.2010.10.004
PMCID: PMC3069908

Genes

ABCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression.PMID 21281810Read ↗

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