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Article

Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population.

Arthritis research & therapy - 31 Jan 2011

Liao Ling-hong, Zhang Hao, Lai Man-Po, Chen Shun-Le, Wu Madeline, Shen Nan

Abstract excerpt

INTRODUCTION: Cytochrome P-450 2E1 (CYP2E1) is an important member of the CYP superfamily, which is involved in the metabolism and activation of many low molecular weight toxic compounds. We tried to investigate the possible association of CYP2E1 tag single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese Han population. METHODS: The coding and flanking...

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Identifiers

PMID: 21281483
DOI: 10.1186/ar3232
PMCID: PMC3241355

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