Article
Association study of ACE polymorphisms and systemic lupus erythematosus in Northern Chinese Han population.
Molecular biology reports - 1 Oct 2012
Gong Ai-Min, Li Xin-Yuan, Wang Yi-Qin, Yan Hai-Xia, Xu Zhao-Xia, Feng Zhao, Xie Yi-Qiang, Yin De-Hui, Yang Shi-Zhong
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease, with multiple genetic and environmental factors involving in its etiology. Angiotensin converting enzyme (ACE) gene was reported to have important roles in the development and progression of SLE. In this study, a case-control study was carried out to investigate the effects of seven SNPs and I/D in ACE gene in the development of SLE in Northern China....
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