X-linked dominant Charcot-Marie-Tooth disease and other potential gap-junction diseases of the nervous system.

Abstract excerpt

Gap junctions play important roles in the exchange of information and metabolites in the nervous system. These roles are highlighted by peripheral neuropathy (X-linked dominant Charcot-Marie-Tooth disease) that is associated with mutations in a gap-junction protein (connexin32), resulting in loss of function, and by somatic dysfunctions where changes in expression, organization or function of gap junctions are...

Topics

• Charcot-Marie-Tooth Disease
• Chromosomes
• Connexins
• Gap Junctions
• Mutation
• Peripheral Nervous System Diseases