Article
The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.
Pharmacogenetics and genomics - 1 Feb 2011
Imanaga Junko, Kotegawa Tsutomu, Imai Hiromitsu, Tsutsumi Kimiko, Yoshizato Tsuneaki, Ohyama Tetsuji, Shirasaka Yoshiyuki, Tamai Ikumi, Tateishi Tomonori, Ohashi Kyoichi
Abstract excerpt
OBJECTIVE: The objective was to determine the effects of the SLCO2B1 c.1457C> T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. METHODS: Individuals were divided based on the genotype of SLCO2B1 c.1457C> T (n = 14, c.[1457C]+ c.[= ] 5,c.[1457C]+ c.[1457C> T] 5, and c.[1457C> T]+c.[1457C> T] 4). The oral pharmacokinetics of 60 mg fexofenadine and 5mg midazolam were...
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