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Article

Apple juice greatly reduces systemic exposure to atenolol.

British journal of clinical pharmacology - 1 Jan 2013

Jeon Hyewon, Jang In-Jin, Lee SeungHwan, Ohashi Kyoichi, Kotegawa Tsutomu, Ieiri Ichiro, Cho Joo-Youn, Yoon Seo Hyun, Shin Sang-Goo, Yu Kyung-Sang, Lim Kyoung Soo

Abstract excerpt

AIM: Fruit juice reduces the plasma concentrations of several β-adrenoceptor blockers, likely by inhibiting OATP2B1-mediated intestinal absorption. The aim of this study was to investigate the effects of apple juice on the pharmacokinetics of atenolol. METHODS: Twelve healthy Korean volunteers with genotypes of SLCO2B1 c.1457C> T (*1/*1 (n = 6) and *3/*3 (n = 6)) were enrolled in this study. In a three-phase,...

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PMID: 22574741
DOI: 10.1111/j.1365-2125.2012.04324.x
PMCID: PMC3555056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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