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Article

Sex-Dependent Effects of CYP2D6 on the Pharmacokinetics of Berberine in Humans.

Clinical pharmacology and therapeutics - 1 Jan 2025

Blöcher Jonas A, Meyer-Tönnies Marleen J, Morof Felix, Rönnpagel Vincent, Bethmann Jonas, Vollmer Marcus, Engeli Stefan, Tzvetkov Mladen V

Abstract excerpt

An over-the-counter product berberine (a major alkaloid in goldenseal) is a substrate of the uptake transporter OCT1 and the metabolizing enzyme CYP2D6. The two genes exhibit common functional polymorphisms. Approximately 9% of Europeans and white Americans are either poor CYP2D6 metabolizers or poor OCT1 transporters. In this study, we investigated the effects of OCT1 and CYP2D6 polymorphisms on berberine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39488825
DOI: 10.1002/cpt.3454
PMCID: PMC11652804

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