Article
Characterization and acceptor preference of a soluble meningococcal group C polysialyltransferase.
Journal of bacteriology - 1 Apr 2011
Peterson Dwight C, Arakere Gayathri, Vionnet Justine, McCarthy Pumtiwitt C, Vann Willie F
Abstract excerpt
Vaccines against Neisseria meningitidis group C are based on its α-2,9-linked polysialic acid capsular polysaccharide. This polysialic acid expressed on the surface of N. meningitidis and in the absence of specific antibody serves to evade host defense mechanisms. The polysialyltransferase (PST) that forms the group C polysialic acid (NmC PST) is located in the cytoplasmic membrane. Until recently, detailed...
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