Characterization of cpsF and its product CMP-N-acetylneuraminic acid synthetase, a group B streptococcal enzyme that can function in K1 capsular polysaccharide biosynthesis in Escherichia coli.

doi:10.1046/j.1365-2958.1996.395931.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Characterization of cpsF and its product CMP-N-acetylneuraminic acid synthetase, a group B streptococcal enzyme that can function in K1 capsular polysaccharide biosynthesis in Escherichia coli.

Molecular microbiology - 1 Feb 1996

Haft R F, Wessels M R, Mebane M F, Conaty N, Rubens C E

Abstract excerpt

Group B Streptococcus (GBS) is the foremost cause of neonatal sepsis and meningitis in the United States. A major virulence factor for GBS is its capsular polysaccharide, a high molecular weight polymer of branched oligosaccharide subunits. N-acetylneuraminic acid (Neu5Ac or sialic acid), at the...

Topics

Antigens, Bacterial
Bacterial Capsules
Base Sequence
Chromosome Mapping
Cloning, Molecular
Electrophoresis, Polyacrylamide Gel
Escherichia coli
Gene Expression Regulation, Bacterial
Genes, Bacterial
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunodiffusion

Molecular Sequence Data

Mutation

N-Acylneuraminate Cytidylyltransferase

Polysaccharides, Bacterial

Streptococcus agalactiae

Transformation, Bacterial

Source

Open in PubMed

Identifiers

PMID: 8830246
DOI: 10.1046/j.1365-2958.1996.395931.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8830246-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of cpsF and its product CMP-N-acetylneuraminic acid synthetase, a group B streptococcal enzyme that can function in K1 capsular polysaccharide biosynthesis in Escherichia coli.PMID 8830246Read ↗

Nucleotide sequence and genetic analysis of the neuD and neuB genes in region 2 of the polysialic acid gene cluster of Escherichia coli K1.Semantic proximity Read ↗

Functional relationships of the sialyltransferases involved in expression of the polysialic acid capsules of Escherichia coli K1 and K92 and Neisseria meningitidis groups B or C.Semantic proximity Read ↗

CpsK of Streptococcus agalactiae exhibits alpha2,3-sialyltransferase activity in Haemophilus ducreyi.Semantic proximity Read ↗

CMP-N-acetylneuraminic acid synthetase from Escherichia coli K1 is a bifunctional enzyme: identification of minimal catalytic domain for synthetase activity and novel functional domain for platelet-activating factor acetylhydrolase activity.Semantic proximity Read ↗

NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus.Semantic proximity Read ↗

The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters.Semantic proximity Read ↗

The capsule polymerase CslB of Neisseria meningitidis serogroup L catalyzes the synthesis of a complex trimeric repeating unit comprising glycosidic and phosphodiester linkages.Semantic proximity Read ↗

Sialylation of Group B Streptococcal Capsular Polysaccharide Is Mediated by<i>cpsK</i>and Is Required for Optimal Capsule Polymerization and ExpressionSemantic proximity Read ↗

Identification of a genetic locus essential for capsule sialylation in type III group B streptococci.Semantic proximity Read ↗

Requirement of NMB0065 for connecting assembly and export of sialic acid capsular polysaccharides in Neisseria meningitidis.Semantic proximity Read ↗

Discovery and characterization of sialic acid O-acetylation in group B <i>Streptococcus</i>Semantic proximity Read ↗

Evidence for a common molecular origin of the capsule gene loci in Gram‐negative bacteria expressing group II capsular polysaccharidesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.