Article
Linkage analysis of autopsy-confirmed familial Alzheimer disease supports an Alzheimer disease locus in 8q24.
Dementia and geriatric cognitive disorders - 1 Jan 2011
Sillén Anna, Brohede Jesper, Forsell Charlotte, Lilius Lena, Andrade Jorge, Odeberg Jacob, Kimura Toru, Winblad Bengt, Graff Caroline
Abstract excerpt
BACKGROUND/AIMS: We have previously reported the results of an extended genome-wide scan of Swedish Alzheimer disease (AD)-affected families; in this paper, we analyzed a subset of these families with autopsy-confirmed AD. METHODS: We report the fine-mapping, using both microsatellite markers and single-nucleotide polymorphisms (SNPs), in the observed maximum logarithm of the odds (LOD)-2 unit (LOD(max)-2) region...
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