Article
Rapid pneumococcal evolution in response to clinical interventions.
Science (New York, N.Y.) - 28 Jan 2011
Croucher Nicholas J, Harris Simon R, Fraser Christophe, Quail Michael A, Burton John, van der Linden Mark, McGee Lesley, von Gottberg Anne, Song Jae Hoon, Ko Kwan Soo, Pichon Bruno, Baker Stephen, Parry Christopher M, Lambertsen Lotte M, Shahinas Dea, Pillai Dylan R, Mitchell Timothy J, Dougan Gordon, Tomasz Alexander, Klugman Keith P, Parkhill Julian, Hanage William P, Bentley Stephen D
Abstract excerpt
Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes...
Topics
- Adaptation, Physiological
- Anti-Bacterial Agents
- Antigenic Variation
- DNA Transposable Elements
- Drug Resistance, Multiple, Bacterial
- Evolution, Molecular
- Genome, Bacterial
- Humans