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Immortalized mouse floxed Bmp2 dental papilla mesenchymal cell lines preserve odontoblastic phenotype and respond to BMP2.

Journal of cellular physiology - 1 Oct 2010

Wu Li-an, Feng Junsheng, Wang Lynn, Mu Yan-dong, Baker Andrew, Donly Kevin J, Gluhak-Heinrich Jelica, Harris Stephen E, MacDougall Mary, Chen Shuo

Abstract excerpt

Bone morphogenetic protein 2 (Bmp2) is essential for odontogensis and dentin mineralization. Generation of floxed Bmp2 dental mesenchymal cell lines is a valuable application for studying the effects of Bmp2 on dental mesenchymal cell differentiation and its signaling pathways during dentinogenesis. Limitation of the primary culture of dental mesenchymal cells has led to the development of cell lines that serve...

Topics

Animals
Biomarkers
Bone Morphogenetic Protein 2
Calcification, Physiologic
Cell Differentiation
Cell Line
Cell Shape
Dental Papilla
Mesenchymal Stem Cells
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Odontoblasts

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 20458728
DOI: 10.1002/jcp.22204
PMCID: PMC2980836

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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