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Article

Establishment of an osteoblast-like cell line, MMC2, from p53-deficient mice.

Bone - 1 Oct 1997

Nakayama T, Kanoe H, Sasaki M S, Aizawa S, Nakamura T, Toguchida J

Abstract excerpt

An immortalized cell line exhibiting a well-differentiated osteoblast-like phenotype was established from calvaria of p53 tumor suppressor-deficient mice. This cell line, designated MMC2, showed several osteoblast-like properties such as high alkaline phosphatase activity, expression of type I collagen and osteocalcin mRNA, and differentiated in vitro to produce mineralized extracellular matrix. Alkaline...

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PMID: 9315334
DOI: 10.1016/s8756-3282(97)00152-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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