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Article

Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts.

Ophthalmic genetics - 1 Jun 2011

Rudolph Thiemo, Sjölander Annica, Palmér Mona Seibt, Minthon Lennart, Wallin Anders, Andreasen Niels, Tasa Gunnar, Juronen Erkki, Blennow Kaj, Zetterberg Henrik, Zetterberg Madeleine

Abstract excerpt

BACKGROUND: Cataract is characterized by light-scattering protein aggregates. The ubiquitin-proteasome system has been proposed a role in proteolytic removal of these protein aggregates. Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is a de-ubiquitinating enzyme with important functions in recycling of ubiquitin. A protective role of the p.S18Y polymorphism of the UCHL1 gene has been shown in Parkinson`s...

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Identifiers

PMID: 21268678
DOI: 10.3109/13816810.2010.544360
PMCID: PMC3116718

Genes

UCHL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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