Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functionalized Scaffold-mediated Interleukin 10 Gene Delivery Significantly Improves Survival Rates of Stem Cells In Vivo

25 Jan 2011

Abstract excerpt

While stem cell transplantation could potentially treat a variety of disorders, clinical studies have not yet demonstrated conclusive benefits. This may be partly because transplanted stem cells have low survival rates, potentially due to host inflammation. The system described herein used two different gene therapy techniques to improve retention of rat mesenchymal stem cells. In the first, stem cells were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to Pluripotent Stem Cells Research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21266957
DOI: 10.1038/mt.2010.311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functionalized Scaffold-mediated Interleukin 10 Gene Delivery Significantly Improves Survival Rates of Stem Cells In VivoPMID 21266957Read ↗

Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold.Semantic proximity Read ↗

IL-10-Functionalized Hydrogels Support Immunosuppressive Dendritic Cell Phenotype and Function.Semantic proximity Read ↗

Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype.Semantic proximity Read ↗

IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation.Semantic proximity Read ↗

Localized immunomodulation with cytokine-producing cells to mitigate host immune rejection responses in rodents and a non-human primateSemantic proximity Read ↗

Biomaterial Scaffolds for Controlled, Localized Gene Delivery of Regenerative FactorsSemantic proximity Read ↗

An SDF-1α gene-activated collagen scaffold restores pro-angiogenic wound healing features in human diabetic adipose-derived stem cellsSemantic proximity Read ↗

Controlled Delivery of Immunomodulators from a Biomaterial Scaffold Niche to Induce a Tolerogenic Phenotype in Human Dendritic Cells.Semantic proximity Read ↗

IGF-1 Peptide Mimetic-functionalized Hydrogels Enhance MSC Survival and Immunomodulatory ActivitySemantic proximity Read ↗

Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic painSemantic proximity Read ↗

A photopolymerizable hydrogel enhances intramyocardial vascular cell delivery and promotes post-myocardial infarction healing by polarizing pro-regenerative neutrophilsSemantic proximity Read ↗

Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.