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Article

Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold.

Biomaterials - 1 Feb 2012

Holladay Carolyn A, Duffy Aoife M, Chen Xizhe, Sefton Michael V, O'Brien Timothy D, Pandit Abhay S

Abstract excerpt

Stem cell transplantation has been suggested as a treatment for myocardial infarction, but clinical studies have yet to demonstrate conclusive, positive effects. This may be related to poor survival of the transplanted stem cells due to the inflammatory response following myocardial infarction. To address this, a scaffold-based stem cell delivery system was functionalised with anti-inflammatory plasmids...

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PMID: 22078809
DOI: 10.1016/j.biomaterials.2011.10.019

Genes

MSC

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