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Article

A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer.

BJU international - 5 Aug 2008

Sharifi Nima, Hamada Akinobu, Sissung Tristan, Danesi Romano, Venzon David, Baum Caitlin, Gulley James L, Price Douglas K, Dahut William L, Figg William D

Abstract excerpt

OBJECTIVE: To determine if patients with advanced prostate cancer carrying a polymorphism that codes for a more active testosterone transporter have less durable responses to androgen-deprivation therapy (ADT) than patients not carrying this polymorphism. PATIENTS AND METHODS: We previously determined that a polymorphism in SLCO1B3 affects testosterone transport and that those men who have at least one wild-type...

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Share to Androgen Antagonists
Share to Antineoplastic Agents, Hormonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

Share to Neoplasms, Hormone-Dependent

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Share to Prostate-Specific Antigen

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Source

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Identifiers

PMID: 18537956
DOI: 10.1111/j.1464-410X.2008.07629.x
PMCID: PMC2574946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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