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Article

The Menin Tumor Suppressor Protein Is Phosphorylated in Response to DNA Damage

14 Jan 2011

Abstract excerpt

BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a heritable cancer syndrome characterized by tumors of the pituitary, pancreas and parathyroid. Menin, the product of the MEN1 gene, is a tumor suppressor protein that functions in part through the regulation of transcription mediated by interactions with chromatin modifying enzymes. PRINCIPAL FINDINGS: Here we show menin association with the 5' regions of...

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PMID: 21264250
DOI: 10.1371/journal.pone.0016119

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The Menin Tumor Suppressor Protein Is Phosphorylated in Response to DNA DamagePMID 21264250Read ↗

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Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1Semantic proximity Read ↗

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