Article
Contribution of allelic variations in transporters to the phenotype of drug response.
Journal of psychopharmacology (Oxford, England) - 1 Jul 2006
Kirchheiner Julia, Gründemann Dirk, Schömig Edgar
Abstract excerpt
Pharmacogenomics seeks to explain the variability in drug response. Neurotransmitter transporters from the SLCA6 family are direct or indirect targets for psychotropic drugs, and their genetic variations may directly influence response to antidepressant or antipsychotic drugs. Furthermore, drug transporters located in natural barriers, such as the blood brain barrier, may influence response to psychoactive...
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