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Article

Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children.

Scientific reports - 16 Feb 2017

Zhang Pingping, Zhang Nan, Liu Linlin, Zheng Kai, Zhu Liang, Zhu Junping, Cao Lina, Jiang Yiyuan, Liu Gang, He Qiushui

Abstract excerpt

Toll-like receptors (TLRs) play a crucial role in innate immunity, protecting the host from bacterial pathogens. We investigated whether bacterial meningitis (BM) in children was associated with gene polymorphisms in TLR2 (rs3804099), TLR3 (rs3775291 and rs3775290) and TLR9 (rs352139 and rs352140). Blood samples were taken from 218 child patients with confirmed BM and 330 healthy adult controls (HC) and...

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Source

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Identifiers

PMID: 28202935
DOI: 10.1038/srep42796
PMCID: PMC5311876

Genes

TLR9
TLR2
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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