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Article

IL28B single nucleotide polymorphisms in the treatment of hepatitis C.

Journal of hepatology - 1 Sept 2011

Lange Christian M, Zeuzem Stefan

Abstract excerpt

Recent genome-wide association studies (GWAS) have identified genetic variations near the IL28B gene which are strongly associated with spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection. Protective IL28B variations are strongly associated with on-treatment viral kinetics and approximately 2-fold increased sustained virologic response (SVR) rates in HCV genotype 1 and 4 patients. In...

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PMID: 21440591
DOI: 10.1016/j.jhep.2011.03.006

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