Article
Role of Interleukin 28B Polymorphisms in Response to Interferon Based Therapy for Hepatitis C Virus Clearance.
Current drug metabolism - 1 Jan 2018
Asthana Manu, Sahu Sushil Kumar, Kumar Amit, Mohanty Suchitra, Chakrabarti Sudipta, Das Piyanki, Chattopadhya Nabanita Roy, Chatterjee Koustav, Singh Shivaram Prasad, Rajasubramaniam Shanmugam, Choudhuri Tathagata
Abstract excerpt
BACKGROUND: Interleukin-28B (IL28B) locus on a human chromosomal region mapped to 19q13 execute immune defense against viruses. During Hepatitis C Virus (HCV) infection the IL28B has a promising role in deciding the consequence of infection for spontaneous clearance of viruses or causing chronic liver infection. Treatment of chronic hepatitis C includes use of direct acting antivirals, Pegylated-Interferon...
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