Article
IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use?
Acta gastro-enterologica Belgica - 1 Jun 2011
Orlent Hans, Reynaert Hendrik, Bourgeois Stefan, Dideberg Vinciane, Adler Michael, Colle Isabelle, De Maeght Stéphane, Laleman Wim, Michielsen Peter, Moreno Christophe, Mulkay Jean-Pierre, Stärkel Peter, Delwaide Jean
Abstract excerpt
Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin....
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