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Article

Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation.

The Journal of clinical investigation - 1 Jun 2004

Dezawa Mari, Kanno Hiroshi, Hoshino Mikio, Cho Hirotomi, Matsumoto Naoya, Itokazu Yutaka, Tajima Nobuyoshi, Yamada Hitoshi, Sawada Hajime, Ishikawa Hiroto, Mimura Toshirou, Kitada Masaaki, Suzuki Yoshihisa, Ide Chizuka

Abstract excerpt

Bone marrow stromal cells (MSCs) have the capability under specific conditions of differentiating into various cell types such as osteocytes, chondrocytes, and adipocytes. Here we demonstrate a highly efficient and specific induction of cells with neuronal characteristics, without glial differentiation, from both rat and human MSCs using gene transfection with Notch intracellular domain (NICD) and subsequent...

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Identifiers

PMID: 15199405
DOI: 10.1172/JCI20935
PMCID: PMC420509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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