Article
Reduction of benzene toxicity by toluene.
Environmental and molecular mutagenesis - 1 Jan 1994
Plappert U, Barthel E, Seidel H J
Abstract excerpt
BDF1 mice were exposed in inhalation chambers to benzene (900 ppm, 300 ppm) and/or toluene (500 ppm, 250 ppm) 6 hr per day, 5 days per week, for up to 8 weeks. Benzene alone induced a slight anemia after 4 and 8 weeks and a reduction of BFU-E and CFU-E numbers in the marrow. The coexposure to toluene reduced the degree of anemia. These results confirm previous studies where toluene was found to reduce benzene...
Topics
- Administration, Inhalation
- Anemia
- Animals
- Benzene
- Bone Marrow
- Cells, Cultured
- DNA Damage
- Erythrocyte Count
- Erythroid Precursor Cells
- Female
- Liver
- Lymphocytes